Divergent total syntheses of lyconadins A and C.
نویسندگان
چکیده
Divergent and concise total syntheses of two lycopodium alkaloids, lyconadins A and C have been developed. The synthesis of lyconadin A, having potent neurotrophic activity, features an efficient one-pot ketal removal and formal aza-[4+2] cyclization to form the cagelike core structure. A tandem ketal removal/Mannich reaction was developed to build the tricyclic structure of lyconadin C. Both lyconadins A and C were synthesized from a pivotal intermediate.
منابع مشابه
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 53 15 شماره
صفحات -
تاریخ انتشار 2014